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Deborah Fowell

Deborah Fowell, Microbiology & Immunology

We are actively engaged in defining the signals that enable effector T cells to ‘find’ areas of infection and damage within inflamed tissues. We utilize intravital multiphoton microscopy and optogenetic tools to visualize and manipulate effector CD4+ T cells in situ. These approaches have revealed extrinsic control of effector CD4+ T cell movement; with roles for chemokines in regulating accumulation and activation at inflamed sites, and roles for T cell integrins in promoting interactions with the extracellular matrix for guided movement. Intrinsic programming of effector CD4+ T cell subsets sets distinct thresholds for sensitivity to these extrinsic cues. By identifying key parameters for T cell effector activity in the inflamed dermis we aim to inform new inflammation-specific therapies.

Title: Professor, Chair

Department: Microbiology & Immunology

Roles: Faculty, Potential MFF (REU) Host

Research Areas: Animal Hosts, Bacteria, Disease Ecology and Evolution, Genetics, Genomics and Cell Biology of Infection, Veterinary/Clinical Research, Viruses