Research Area: Animal Hosts

The Flyak lab studies human antibody response to viral pathogens. We try to answer questions like, how do human antibodies neutralize rapidly mutating viruses? And, how can we design vaccines that mimic effective antibody responses seen in some individuals? In our lab, we isolate antibodies[...]

Scott’s research investigates how endocrine signaling networks regulate animals’ physiological responses to pathogenic microbes. He uses the fruit fly Drosophila melanogaster as a genetically tractable model to investigate the mechanisms by which several key insect hormones and their cognate nuclear receptors both directly and indirectly[...]

We study positive and negative interactions between viruses and antibodies. We are particularly interested in maternal antibodies, which are transferred from mother to infant to protect against neonatal infections. However, these antibodies can also block the infant response to vaccines. Despite this phenomenon being identified[...]

We study the transmission and impacts of infectious disease in a changing ocean and mechanisms of immune function in marine invertebrates. We work to identify the value of intact ocean biodiversity and develop strategies towards a healthier ocean.

Climate change dramatically impacts freshwater ecosystems, which are becoming warmer, more acidic, and nutrient rich. The collective influence of the microbial inhabitants of these ecosystems, despite their tiny size, can have an immense impact on water quality. However, we lack fundamental knowledge on the ecology[...]

We are actively engaged in defining the signals that enable effector T cells to ‘find’ areas of infection and damage within inflamed tissues. We utilize intravital multiphoton microscopy and optogenetic tools to visualize and manipulate effector CD4+ T cells in situ. These approaches have revealed extrinsic[...]

I am interested in finding better ways of controlling the mosquito Aedes aegypti, the main vector of dengue and Zika viruses. Specifically, I am interested in determining how they move through their environment and the effect that has on different control strategies. The mosquito virome, the[...]

Research in my lab probes the environmental, structural and physiological basis of bacterial survival. The majority of earth’s microbes exist in a non-growing, surival state, making it important to better understand the mechanisms underpinning this physiological state. We primarily use the environmental zoonotic pathogen, Coxiella burnetii (causative agent[...]

Janelle’s research project aims to understand how diet affects the microbiome, and how these diet-dependent microbiome changes affect the immune system- particularly CD8+ T cells. Her work also uses flow cytometry and sequencing to look at how diet and microbiome changes in early life affects[...]

Macrophages are susceptible to HIV-1 infection and are resistant to virally-induced cell death. Alveolar macrophages (AM) in particular are known to be extremely long-lived and self-renewing, and have been shown to be both permissive to HIV-1 infection and persist in the face of Anti-Retroviral Therapy[...]