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Tag: Genetics, Genomics and Cell Biology of Infection

  1. Hector Aguilar-Carreno

    The main focus of our research program is to elucidate key mechanistic components in enveloped viruses and their host cells that: 1) mediate viral entry into cells, 2) elicit cell immune responses, and 3) mediate viral egress from cells. These studies are leading to the[...]
  2. Mosquito venereal transmission of arboviruses.

    Dengue (DEN) is the most prevalent arthropod-borne viral (arboviral) disease in the world; DEN disease incidence has increased dramatically in the last 50 years. Ae. aegypti is the most important vector of DENV to human hosts and the vector remains persistently infected with DENV for life. Understanding interepidemic maintenance of the virus is essential for […]

  3. Avery August

    The August lab is interested in infection-based and environment signals that trigger inflammation. We are particularly interested in signals regulated by the Tec family kinases, and how they regulate activation of cells such as mast cells and T cells to drive their differentiation and production[...]
  4. Gary Blissard, Boyce Thompson Institute

    Gary Blissard

    The Blissard lab addresses fundamental questions on the biology and pathology of virus-insect interactions. A primary focus is the study of viral envelope glycoproteins and their interactions with host insect cells and cell proteins during viral entry and egress. Another focus are is understanding the[...]
  5. Adam Bognadove, Plant Pathology and Plant-Microbe Biology

    Adam Bogdanove

    Our research centers on crop diseases caused by bacteria in the genus Xanthomonas, focusing on TAL effector proteins injected by the bacteria to manipulate expression of specific host genes important for disease development. Our lab also studies plant disease resistance mechanisms triggered by TAL effectors[...]
  6. Ilana Brito

    I study how microbes in the human microbiome are transmitted among individuals, using a wide range of approached including shotgun metagenomics of microbiome communities, culture-based methods, and single-cell analyses. Another main focus is horizontal transmission of genes between members of the microbiome, specifically focusing on[...]
  7. Nicholas Buchon, Department of Entomology

    Nicolas Buchon

    The Buchon lab focuses on the impact of pathogens and the microbiota on body homeostasis. We use systemic infection as a model for septicemia, and the gut response to infection as a model for mucosal immunity. Genomic and genetic approaches allow us to characterize new[...]
  8. Clare Casteel, PPPMB

    Clare Casteel

    Numerous studies demonstrate that vector-borne pathogens influence host characteristics, resulting in altered host-vector interactions and enhanced transmission. We seek to determine the molecular mechanisms that underlie this phenomenon and use this knowledge to develop innovative control strategies using genetic and biochemical approaches. Current focuses are[...]
  9. Pamela Chang, Immunology and Chemical Biology

    Pamela Chang

    Our research focuses primarily on three areas: We develop activity-based probes to understand the metabolic activity catalyzed by the gut microbiome during different disease states. We also characterize the small-molecule metabolites produced by the gut microbiota that regulate inflammation during inflammatory diseases and host defense[...]
  10. Yung-Fu Chang, Population Medicine and Diagnostic Sciences

    Yung-Fu Chang

    My research focuses on the pathogenesis of bacterial diseases and vaccine protection mechanisms.  My lab is working on the interaction of host receptors and virulence factors of C. difficile (toxins), Leptospira spp, and F. nucleatum (adhesins).  We are also working on the mucosa immunity against F. nucleatum and M. avium subsp. paratuberculosis using outer membrane vesicle[...]