Our research is directed at characterizing structures and biological function of biogenic small molecules (BSMs) that regulate development and immune responses in plants and animals and serve important functions with associated microbiota. Using comparative metabolomic approaches we have engaged in a comprehensive effort to characterize structures and functions of all BSMs (more than 20,000 small molecules) produced by the model organism Caenorhabditis elegans, with a specific cofus on signaling molecules that regulate organismal development and interactions with microbiota.
Department: Boyce-Thompson Institute, Chemistry and Chemical Biology
Roles: Faculty Investigator
Research Areas: Animal Hosts, Bacteria, Disease Ecology and Evolution, Genetics, Genomics and Cell Biology of Infection, Microbiota and Microbiomes, Plant Hosts