Tag: Genomics and Cell Biology of Infection

The intestinal epithelium faces unique challenges as it is constantly exposed to the passage of ingested material including food, bacteria and xenobiotics. To maintain tissue function, the intestinal epithelium is undergoing continuous renewal mediated by intestinal stem cells (ISCs). ISC proliferation and differentiation are constantly adapted both to the microbes present and to the gut […]

The main focus of our research program is to elucidate key mechanistic components in enveloped viruses and their target host cells that: 1] mediate viral entry into cells, 2] elicit cell immune responses, and 3] mediate viral egress from cells. Within our lab, these studies lead to the design, development, and testing of novel antiviral agents […]

The Brito Lab is recruiting postdocs in direct host-microbiome interactions that may modulate health. We are specifically interested in exploring bacterial proteins that can alter host cellular functions. We are looking for individuals with either computational or wet lab experience, or both. Interested candidates will be able to explore the mechanistic underpinnings of microbiome-related disorders […]

Development of broadly neutralizing antibodies to influenza using a novel bacterial outer membrane vesicle platform: The Leifer and Putnam labs have an ongoing collaboration to use innovative engineering techniques develop, test, and understand the underlying immunological mechanisms of new vaccine adjuvant bacterial outer membrane vesicle platforms. We are interested in postdoctoral candidates proposing to take […]

The Hendry lab uses experimental and -omics approaches to understand the impact of host interactions on bacterial ecology and evolution, as well as how microbes influence hosts. Research in the lab focuses on a variety of systems, particularly insect and plant associated bacteria. Our interdisciplinary group encompasses broad interests within microbiology, evolution, and ecology and […]

The Moreau lab focuses on the symbiotic factors that drive speciation, adaptation, and evolutionary diversification.  Much of the research in the lab focuses on the potential co-evolution of ants and their gut-associated bacteria to understand the diversity and putative function of host-associated microbes.  By coupling this information with data on diet, trophic ecology, evolutionary history […]

The research in the Kessler Lab focuses on the ecology and evolution of plant chemical defenses (secondary metabolites) to pathogens and herbivores and the role of soil microbial communities to affect and be affected by plant secondary metabolism. Thus we try to understand how microbially-mediated plant-soil feedbacks influence the macroscopic interactions of plants with their […]

The Hendry lab studies the evolution and ecology of bacteria interacting with animal hosts, particularly insects. Study systems include both pathogenic interactions of bacteria with agriculturally important insects and mutualistic interactions where bacterial symbionts influence insect ecology and evolution. There are several undergraduate research opportunities in the lab using techniques in microbiology, ecological experiments, and […]

The Helmann lab investigates adaptation to stress using Bacillus subtilis as a model organism. One project focuses on the roles of alternative sigma factors and other regulators in controlling cell envelope stress responses. These studies support our ongoing work on the molecular mechanisms of antibiotic resistance. A second major research effort is directed at metal ion homeostasis. Metal regulation plays […]

The Heck lab deciphers molecular mechanisms regulating insect transmission of plant pathogens and uses this knowledge to create practical solutions that mitigate vector-borne diseases in agriculture. We use a combination of computational and wet-lab approaches to study vector-pathogen-plant interactions. Students will receive training at the intersections of computational biology, plant pathology, entomology, microbiology, genetic engineering […]