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Tag: Genomics and Cell Biology of Infection

  1. Vector Aedes aegypti, from functional genetics to ecological analyses

    Mosquitoes cause 400,000 malaria deaths and transmit viruses to hundreds of millions. The vectorial capacity of mosquitoes depends on their ability to survive infection. However, it remains unclear what key mechanisms underlie the mosquito tolerance and resistance to infection with multiple microbes (bacteria, fungi, microbiota, viruses). We are particularly interested in approaches ranging from lab controlled […]

  2. Exploring host-microbe interactions related to metabolic disorders

    The Brito Lab is recruiting postdocs in direct host-microbiome interactions that may modulate health. We are specifically interested in exploring bacterial proteins that can alter host cellular functions. We are looking for individuals with either computational or wet lab experience, or both. Interested candidates will be able to explore the mechanistic underpinnings of microbiome-related disorders […]

  3. Iris Holmes, CIHMID Postdoc Fellow

    Iris Holmes

    Iris explores the ways that vertebrate hosts cope with infections from the diverse community of parasites they encounter throughout their lives. Specifically, she looks at signatures of selection on the immune genes of lizards, and correlate those signatures with the lizard’s parasite community. Iris is[...]
  4. Development of broadly neutralizing antibodies to influenza

    Development of broadly neutralizing antibodies to influenza using a novel bacterial outer membrane vesicle platform: The Leifer and Putnam labs have an ongoing collaboration to use innovative engineering techniques develop, test, and understand the underlying immunological mechanisms of new vaccine adjuvant bacterial outer membrane vesicle platforms. We are interested in postdoctoral candidates proposing to take […]

  5. Ecology and Evolution in Bacteria-Host Interactions

    The Hendry lab uses experimental and -omics approaches to understand the impact of host interactions on bacterial ecology and evolution, as well as how microbes influence hosts. Research in the lab focuses on a variety of systems, particularly insect and plant associated bacteria. Our interdisciplinary group encompasses broad interests within microbiology, evolution, and ecology and […]

  6. Mechanisms of Virus-Host Interactions

    The main focus of our research program is to elucidate key mechanistic components in enveloped viruses and their target host cells that: 1] mediate viral entry into cells, 2] elicit cell immune responses, and 3] mediate viral egress from cells. Within our lab, these studies lead to the design, development, and testing of novel antiviral agents […]

  7. microscope work

    Opportunistic infections at the host-pathogen interface

    Opportunistic pathogens can subvert infection barriers (e.g., host immune functions and nutrient limitations) and switch from peaceful commensal to potentially lethal pathogen. The factors promoting either outcome are unknown, but must be shaped by dynamic physiological interactions between host and pathogen. This project aims to determine key factors at the host-pathogen interface that mediate the […]

  8. Adam Bogdanove lab

    The Bogdanove lab’s research centers on the development of broad-spectrum, durable disease resistance in crop plants with a focus on diseases caused by bacteria that deploy host DNA binding proteins called TAL effectors. We also continue to be interested in the use of TAL effectors as customizable DNA targeting tools for applications such as targeted […]

  9. Michelle Heck lab

    The Heck lab deciphers molecular mechanisms regulating insect transmission of plant pathogens and uses this knowledge to create practical solutions that mitigate vector-borne diseases in agriculture. We use a combination of computational and wet-lab approaches to study vector-pathogen-plant interactions. Students will receive training at the intersections of computational biology, plant pathology, entomology, microbiology, genetic engineering […]

  10. John Helmann lab

    The Helmann lab investigates adaptation to stress using Bacillus subtilis as a model organism. One project focuses on the roles of alternative sigma factors and other regulators in controlling cell envelope stress responses. These studies support our ongoing work on the molecular mechanisms of antibiotic resistance. A second major research effort is directed at metal ion homeostasis. Metal regulation plays […]