Tag: Genetics, Genomics and Cell Biology of Infection

Our research is focused on understanding how plants protect themselves against microbial pathogens at molecular and cellular levels. Major goals are to determine the mechanisms of salicylic acid (SA) activation and regulation of the plant’s immune responses, and to identify new targets or aspirin (acetyl[...]

The research in the Kessler Lab focuses on the ecology and evolution of plant chemical defenses (secondary metabolites) to pathogens and herbivores and the role of soil microbial communities to affect and be affected by plant secondary metabolism. Thus we try to understand how microbially-mediated[...]

My research is focused on the eukaryotic cell DNA damage response (DDR) to a novel bacterial genotoxin called cytolethal distending toxin (CDT) within the context of intestinal disease of human and animals. I also have extensive experience in the development and assessment of laboratory animal[...]

We study the molecular evolution and population genetics of the immune system in Drosophila and other insects, specifically focusing on comparative genomics and transcriptional regulation of the immune response. We also explore host genetic variation in microbiome composition and function in a large human twin study and[...]

My research focuses on the pathogenesis of bacterial diseases and vaccine protection mechanisms.  My lab is working on the interaction of host receptors and virulence factors of C. difficile (toxins), Leptospira spp, and F. nucleatum (adhesins).  We are also working on the mucosa immunity against F. nucleatum and M. avium subsp. paratuberculosis using outer membrane vesicle[...]

My lab has a broad interest in the structure and function of viral envelope proteins, and how genomic mutations lead to changes in the envelope proteins and control viral pathogenesis. We primarily study influenza viruses of humans and animals, and coronaviruses, principally, SARS-CoV, MERS-CoV and[...]

We study how M.tuberculosis is capable of surviving within humans for decades in the face of a fully competent immune response.  Our focus is primarily on the bacterial pathways, innate immunity, and the evolution of bacterial drug resistance in mammalian hosts.

The Turgeon lab works on mechanisms of fungal virulence to plants with particular emphasis on the roles of fungal secondary metabolites, iron and oxidative stress. Classical genetic, molecular genetic, and genomic approaches are used.

The unifying themes of my ongoing research program are seeking to understand the underlying mechanisms that control the pathogenesis and disease associated with bacterial infections, as well as developing control strategies for the bacteria or its associated disease. The main focus for the past years[...]

Two main areas of study in the Smart lab include identifying genes in bacterial pathogens that enable movement within a plant, and understanding the population diversity of rapidly reproducing oomycete pathogens. These studies enhance our knowledge of pathogen virulence determinants and further elucidate how plants[...]